The N tires have a lower load rating and after running 7 sets of tires on my Macan, that means more comfort, since they are tuned for the weight and uses of the Macan. The PS4 SUV, as a non-N tire, needs to handle any SUV use so the load rating is higher (and weight too) which results in a less comfortable ride. OE is 104 and 106 vs. 108 and 110. I loved them though, the traction in wet or dry was truly phenomenal.
I agree with your choice, if I were to choose a 20" OE Macan summer tire, it would be the LS3. As a wildcard, my new favorite 20" tire is the N0 Michelin Pilot Sport A/S 3 for the Cayenne. They are a larger diameter and width at 275/45 and 305/40 so you get the bonus of a super comfortable ride and more contact patch without compromising handling.
I switch back-to-back with a set of 21" forged turbo designs with NE0 PS4 A/S and these Cayenne tires don't feel numb or sloshy given the massive difference in sidewall between the two. They feel dialed-in like a performance tire but also deliver the benefits of a larger sidewall. Probably a factor of the extra high load rating (stiff sidewall) of 110 and 112 but offset with comfort by the extra sidewall height.